Trade name: Absorica, Absorica LD, Claravis, Amnesteem, Myorisan, Zenatane, Accutane.
Generic names: Isotretinoin
Indication and Usage: FDA has approved this prescription medication to treat severe recalcitrant nodular acne.
Ingredients: Isotretinoin, beeswax, butylated hydroxyanisole, edetate disodium, hydrogenated soybean oil flakes, hydrogenated vegetable oil, and soybean oil. Gelatin capsules contain glycerin and parabens (methyl and propyl), with the following dye systems: 10 mg — iron oxide (red) and titanium dioxide; 20 mg — FD&C Red No. 3, FD&C Blue No. 1, and titanium dioxide; 40 mg — FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide.
Manufacturer-listed adverse reactions | Isotretinoincan cause: Allergic reactions including vasculitis, systemic hypersensitivity, edema, fatigue, lymphadenopathy, and weight loss, Palpitation, Tachycardia, Vascular thrombotic disease, Stroke, Hypertriglyceridemia, Alterations in blood sugar levels, Inflammatory bowel disease, Hepatitis, Pancreatitis, Bleeding and inflammation of the gums, Colitis, Esophagitis/esophageal ulceration, Ileitis, Nausea and other nonspecific gastrointestinal symptoms, Anemia, Thrombocytopenia, Neutropenia, Rare reports of agranulocytosis, Skeletal hyperostosis, Calcification of tendons and ligaments, Premature epiphyseal closure, Decreases in bone mineral density, Musculoskeletal symptoms (sometimes severe) including back pain, myalgia, and arthralgia, Transient pain in the chest, Arthritis, Tendonitis, Other types of bone abnormalities, Elevations of CPK/rare reports of rhabdomyolysis, Pseudotumor cerebri, Dizziness, Drowsiness, Headache, Insomnia, Lethargy, Malaise, Nervousness, Paresthesias, Seizures, Syncope, Weakness, Suicidal ideation, Suicide attempts, Suicide, Depression, Psychosis, Aggression, Violent behaviors, Emotional instability, Abnormal menses (period), Voice alteration, Visual disturbances, Bronchospasms (with or without a history of asthma), Respiratory infection, Acne fulminans, Alopecia (which in some cases persists), Bruising, Cheilitis (dry lips), Epistaxis, Eruptive xanthomas, Flushing, Fragility of skin, Hair abnormalities, Hirsutism, Tinnitus, Keratitis, Optic neuritis, Corneal opacities, Hyperpigmentation/hypopigmentation, Enfections (including disseminated herpes simplex), Paronychia, Pruritus, Pyogenic granuloma, Rash (including facial erythema, seborrhea, and eczema), Sunburn susceptibility increased, Sweating, Urticaria, Photoallergic/photosensitizing reactions, Peeling of palms and soles, Vasculitis (including Wegener’s granulomatosis, Abnormal wound healing (delayed healing or exuberant granulation tissue with crusting), Hearing impairment, Decreased night vision which may persist, Cataracts, Color vision disorder, Conjunctivitis, Eyelid inflammation, Thrombocytopenia, White cells in the urine, Proteinuria, Microscopic or gross hematuria, Nail dystrophy, Photophobia, Glomerulonephritis, Nonspecific urogenital findings, Elevation of plasma triglycerides, Decrease in serum high-density lipoprotein (HDL) levels, Elevations of serum cholesterol during treatment Increased alkaline phosphatase, SGOT (AST), SGPT (ALT), GGTP or LDH, Elevation of fasting blood sugar, elevations of CPK, Hyperuricemia, Dry mouth, nose, skin, and eyes, Decreases in red blood cell parameters, Decreases in white blood cell counts (including severe neutropenia and rare reports of agranulocytosis, Elevated sedimentation rates, and Elevated platelet counts
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