Generic names: Hepatitis A Vaccine, Inactivated
Indication and Usage: The FDA approved this vaccine for the prevention of disease caused by hepatitis A virus (HAV) in persons 12 months of age and older.
Ingredients:
VAQTA is an inactivated whole virus vaccine derived from hepatitis A virus grown in cell culture in human MRC-5 diploid fibroblasts. Each 0.5-mL pediatric dose contains 25U of hepatitis A virus antigen and adsorbed onto approximately 0.225 mg of aluminum provided as amorphous aluminum hydroxyphosphate sulfate, and 35 mcg of sodium borate as a pH stabilizer, in 0.9% sodium chloride. Each 1-mL adult dose contains 50U of hepatitis A virus antigen and adsorbed onto approximately 0.45 mg of aluminum provided as amorphous aluminum hydroxyphosphate sulfate, and 70 mcg of sodium borate as a pH stabilizer, in 0.9% sodium chloride.
HAVRIX is a sterile suspension of inactivated virus for intramuscular administration. The virus (strain HM175) is propagated in MRC-5 human diploid cells. After removal of the cell culture medium, the cells are lysed to form a suspension. Each 1-mL adult dose of vaccine contains 1440 EL.U. of viral antigen, adsorbed on 0.5 mg of aluminum as aluminum hydroxide. Each 0.5-mL pediatric dose of vaccine contains 720 EL.U. of viral antigen, adsorbed onto 0.25 mg of aluminum as aluminum hydroxide. HAVRIX contains the following excipients: Amino acid supplement (0.3% w/v) in a phosphate-buffered saline solution and polysorbate 20 (0.05 mg/mL). From the manufacturing process, HAVRIX also contains residual MRC-5 cellular proteins (not more than 5 mcg/mL), formalin (not more than 0.1 mg/mL), and neomycin sulfate (not more than 40 ng/mL), an aminoglycoside antibiotic included in the cell growth media.
Manufacturer-listed adverse reactions | Hepatitis A vaccine can cause:
Havrix can cause: Rhinitis, Thrombocytopenia, Anaphylactic reaction, Anaphylactoid reaction, Serum sickness–like syndrome, Convulsion, Dizziness, Encephalopathy, Guillain-Barré syndrome, Hypoesthesia, Multiple sclerosis, Myelitis, Paresthesia, Somnolence, Syncope, Vasculitis, Dyspnea, Hepatitis, Jaundice, Angioedema, Erythema multiforme, Hyperhidrosis, Congenital anomaly, Musculoskeletal stiffness, Chills, Influenza-like symptoms, Neuropathy, Injection site reaction, and Local swelling.
Vaqta can cause: Thrombocytopenia, Guillain-Barré syndrome, Cerebellar ataxia, Encephalitis, Diarrhea, and Gastroenteritis
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