Generic names: Rotavirus Vaccine, Live, Oral, Pentavalent Oral Solution
Indication and Usage:
RotaTeq is a vaccine indicated for the prevention of rotavirus gastroenteritis caused by types G1, G2, G3, G4, and G9. RotaTeq is approved for use in infants 6 weeks to 32 weeks of age.
ROTARIX is a vaccine indicated for the prevention of rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9). ROTARIX is approved for use in infants 6 weeks and up to 24 weeks of age.
Ingredients:
RotaTeq is a live, oral pentavalent vaccine that contains 5 live reassortant rotaviruses. The rotavirus parent strains of the reassortants were isolated from human and bovine hosts. Each vaccine dose contains sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, and trace amounts of fetal bovine serum. RotaTeq contains no preservatives.
ROTARIX (Rotavirus Vaccine, Live, Oral), for oral administration, is a live, attenuated rotavirus vaccine derived from the human 89-12 strain which belongs to G1P type. The lyophilized vaccine contains amino acids, dextran, Dulbecco’s Modified Eagle Medium (DMEM), sorbitol, and sucrose. DMEM contains the following ingredients: sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, Lglutamine, calcium chloride, sodium hydrogenocarbonate, and phenol red. The liquid diluent contains calcium carbonate, sterile water, and xanthan. The diluent includes an antacid component (calcium carbonate) to protect the vaccine during passage through the stomach and prevent its inactivation due to the acidic environment of the stomach.
Manufacturer-listed adverse reactions |
RotaTeq can cause: Anaphylactic reaction, Intussusception (including death), Hematochezia, Gastroenteritis (Stomach Flu), Vaccine viral shedding, Urticaria (Hives), Angioedema, Kawasaki disease, and transmission of vaccine virus strains from vaccine recipient to non-vaccinated contacts.
ROTARIX can cause: Intussusception, Death (listed twice), Hematochezia, Gastroenteritis (Stomach Flu), Viral Shedding, Idiopathic thrombocytopenic purpura, Kawasaki disease, Maladministration.
Limitations of Effectiveness: RotaTeq may not protect all vaccine recipients against rotavirus.
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